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Ali Gheissari and Vali Nasr. Democracy in Iran

Tue, 10/21/2014 - 14:43
Ali Gheissari and Vali Nasr. Democracy in Iran

EU-GCC Relations: Dynamics, patterns and perspective

Tue, 10/21/2014 - 14:43
EU-GCC Relations: Dynamics, patterns and perspective

Perspectives on the Guaranteed Income, Part I

Tue, 10/21/2014 - 14:43
Perspectives on the Guaranteed Income, Part I A Review of Six Books on Guaranteed Income: Arguing for Basic Income: Ethical Foundations for a Radical Reform by Philippe Van Parijs; A Review of Six Books on Guaranteed Income: Real Freedom for All: What (If Anything) Can Justify Capitalism? by Philippe Van Parijs; A Review of Six Books on Guaranteed Income: The Benefit of Another's Pains: Parasitism, Scarcity, Basic Income by Gijs van Donselaar; A Review of Six Books on Guaranteed Income: The $30,000 Solution: A Guaranteed Annual Income for Every American by Robert R. Schutz; A Review of Six Books on Guaranteed Income: "And Economic Justice for All": Welfare Reform for the 21st Century by Michael L. Murray; A Review of Six Books on Guaranteed Income: The National Tax Rebate: A New America with Less Government by Leonard M. Greene

Transnational Media, Regional Politics and State Security

Tue, 10/21/2014 - 14:43
Transnational Media, Regional Politics and State Security Saudi Arabia is a crucially important media player in the Middle East, commanding modern, sophisticated and far-reaching media systems. Driving the Saudi media hegemony is what may be loosely termed "a security imperative" which is tightly connected to internal dynamics, geopolitical considerations and regional rivalries. Empowered with its oil wealth, Saudi Arabia pursued a dual media strategy, operating state-controlled and circumscribed domestic media systems which insulate the population from undesired external influences and uphold the religious sensibility of the kingdom while developing decentralized, open and modern transnational media systems abroad capable of safeguarding the kingdom's interests and promoting its foreign policy. Instrumental as it may be in the kingdom's comprehensive security approach, though, the media have proven to be an inordinately complex asset. Although remarkable in many respects, the liberalization of Saudi media engendered a number of conflictual dynamics which are potentially consequential.

Dal Seung Yu. The Role of Political Culture in Iranian Political Development

Tue, 10/21/2014 - 14:43
Dal Seung Yu. The Role of Political Culture in Iranian Political Development

Perspectives on the Guaranteed Income, Part II

Tue, 10/21/2014 - 14:43
Perspectives on the Guaranteed Income, Part II A Review of Nine Books on the Guaranteed Income: Freedom and Security: An Introduction to the Basic Income Debate by Tony Fitzpatrick; A Review of Nine Books on the Guaranteed Income: Basic Income: Economic Security for All Canadians by Sally Lerner; Charles M. A. Clark; W. Robert Needham; A Review of Nine Books on the Guaranteed Income: The Stakeholder Society by Bruce Ackerman; Anne Alstott; A Review of Nine Books on the Guaranteed Income: Socioeconomic Democracy: An Advanced Socioeconomic System by Robley E. George; A Review of Nine Books on the Guaranteed Income: Stumbling towards Basic Income: The Politics for Tax-Benefit Integration by Bill Jordan; Phil Agulnik; Duncan Burbidge; Stuart Duffin; A Review of Nine Books on the Guaranteed Income: Healing Politics: Citizen Policies and the Pursuit of Happiness by Steve Shafarman; A Review of Nine Books on the Guaranteed Income: Basic Income on the Agenda: Policy Objectives and Political Chances by Loek Groot; Robert Jan van der Veen; A Review of Nine Books on the Guaranteed Income: Daily Bread, the Story of Jasper's Box by Stephen C. Clark; A Review of Nine Books on the Guaranteed Income: What's Wrong with a Free Lunch? by Joel Rogers; Joshua Cohen

Utraque Unum 2:2 (2009)

Fri, 10/17/2014 - 13:51
Utraque Unum 2:2 (2009) Schall, James Some articles redacted due to copyright restrictions. Please contact digitalscholarship@georgetown.edu for more information.

Georgetown Public Policy Review Volume 10 Number 2

Wed, 10/15/2014 - 14:48
Georgetown Public Policy Review Volume 10 Number 2

Georgetown Public Policy Review Volume 8 Number 2

Wed, 10/15/2014 - 14:47
Georgetown Public Policy Review Volume 8 Number 2

Georgetown Public Policy Review Number 7 Volume 1

Wed, 10/15/2014 - 14:45
Georgetown Public Policy Review Number 7 Volume 1

Fragile Politics: Weak States in the Greater Middle East

Tue, 10/14/2014 - 10:11
Fragile Politics: Weak States in the Greater Middle East Kamrava, Mehran; Schmitz, Charles; Phillips, Sarah; Esser, Daniel; Wehrey, Frederic; Mikaelian, Shoghig; Salloukh, Bassel F.; Abusharaf, Rogaia; de Waal, Alex; Babar, Zahra; Osman, Dwaa; Robinson, Glenn E.; Brand, Laurie; McGillivray, Mark; Feeny, Simon; De Silva, Ashton This CIRS research initiative on weak states in the Middle East begins with a critical analysis of current definitions and terminology of weak and fragile states, scrutinizing the political implications of the prevailing discourse within the setting of the broader Middle East. The research also examines the domestic, regional, and global causes and consequences for the Middle East of the “fragility” of states stretching from Afghanistan and Pakistan in the east to Libya in the west. Employing multidisciplinary perspectives, the Center for International and Regional Studies examines the causes and implications of conceptual notions of state fragility across the region in relation to areas such as politics and security, economics and natural resources, intra- and inter-state relations, migration and population movements, and the broader regional and global political economies.

Utraque Unum 7:1 (2014)

Thu, 09/11/2014 - 09:53
Utraque Unum 7:1 (2014)

Utraque Unum 6:2 (2013)

Thu, 09/11/2014 - 09:52
Utraque Unum 6:2 (2013)

Utraque Unum 6:1 (2012)

Thu, 09/11/2014 - 09:44
Utraque Unum 6:1 (2012)

Library Associates Newsletter: Issue 110

Fri, 08/22/2014 - 15:37
Library Associates Newsletter: Issue 110 Lauinger Library Landmark Gift Funds Renovation; From the University Librarian: What's In A Name?; New Board Members; Floor Plan; The New Booth Center for Special Collections; Dennis Lockhart on the Economic Outlook; Beyond Foodies: Why Talking About Food Could Change the World with Tracie McMillan; Staff Excellence Awards; The First Tom Sawyer

Erving Goffman and You

Fri, 08/22/2014 - 15:33
Erving Goffman and You Erving Goffman and You is an animated web series that explores the main tenets of sociologist Erving Goffman's The Presentation of Self in Everyday Life. Goffman is best known for using theatrical terminology to analyze mundane interactions. Goffman explained his theories with anecdotal examples, but his anecdotes are not as relatable as they were when the book was published. Erving Goffman and You reboots Goffman's concepts through six modern day examples. The web series relies on a knowledge base that includes both Goffman's work and the work of Goffmanian scholars. The combination of updated examples and visually engaging content provides a fresh take on dramaturgical analysis for newcomers and fans of Goffman alike. M.A.

Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer

Thu, 08/21/2014 - 15:27
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways of following treatment response. We believe that miRNAs play an important role in cancer, and circulating miRNAs from peripheral blood could not only be used as early diagnostic biomarkers, but their expression profile could give us a valuable clue about response to therapy.; We focus on targeting tumor-stroma interaction in a pancreatic cancer xenograft mouse model, with two small molecule inhibitors: (1) a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, PD173074; and (2) an anaplastic lymphoma kinase receptor (ALK) kinase inhibitor, TAE684. Both drugs reduced COLO357PL pancreatic cancer cell proliferation and disruption of endothelial cell monolayer by cancer cells in vitro. In vivo, initial treatment with both drugs reduced mitosis and angiogenesis similarly. First, we identified serum miRNA expression changes as a response to the tumor presence. Furthermore, we describe a distinctive set of circulating miRNAs that corresponds to each initial treatment before necrotic changes took place and influenced miRNA expression pattern. More importantly, in our study we distinguish between drug effect on the tumor versus host, based on the miRNA expression changes in tumor tissue and the circulation. Finally, we show a connection between successful treatment of pancreatic cancer xenografts and the circulating miRNA expression pattern.; The approach of determining circulating miRNA expression levels and patterns upon the initial treatment could be of immense importance for pancreatic cancer patients in finding the effective drug (combination) treatment and might be a model to expand to other cancers and treatment evaluations. Ph.D.

Development of Novel Computational Methodologies for Analyzing Post-Processed Untargeted LC-MS Metabolomics Data

Thu, 08/21/2014 - 15:27
Development of Novel Computational Methodologies for Analyzing Post-Processed Untargeted LC-MS Metabolomics Data In recent years, the field of metabolomics has quickly risen to become a crucial platform for conducting biological research. Its unique capabilities, which provides unparalleled comprehensive quantitative insight into the constituents of metabolic processes, makes the platform a potentially transformative technology. However, it is these novel aspects, coupled with the immaturity of the techniques utilized, which has contributed to the many difficulties faced by pioneers in the field. Nonetheless, its potential for becoming the bedrock technology for gaining a deeper understanding into the metabolic processes behind many biological diseases underscores the importance of advancing the metabolomics platform. A key aspect in advancing the platform is the development of specialized tools for processing the substantial and often cryptic quantitative data that is generated. The sheer volume of data produced, coupled with the specialized knowledge and expertise necessary to understand it, emphasizes the importance in creating automated high throughput tools that enable streamlined analysis and produces meaningful results.; Development of tools for post-processing, which is comprised of the computational methodologies for extracting statistically and biologically relevant conclusions from post-processed metabolomics data, is crucial in cultivating metabolomics into a more complete and mature platform. In pursuit of these objectives, we have developed three computational methodologies that attempt to take advantage of the strengths of metabolomics data sets while at the same time accounting for its shortcomings. Initial efforts resulted in the creation of the Visual Analysis of Metabolomics Package (VAMP), a tool that allows for all small molecule components in the metabolome to be holistically visualized and qualitatively evaluated. The necessity for a more quantitative approach led to the development of MetaboLyzer, an analysis workflow that incorporates many classical univariate and multivariate biostatistical approaches. Finally, an attempt to make a truly novel algorithm for the express purpose of analyzing metabolomics data resulted in Selective Paired Ion contrast Analysis (SPICA), a methodology that relies on analyzing ion-pairs rather than single-ions, which affords numerous advantages in minimizing normalization issues and noise reduction. Taken together, these efforts represent what is hopefully a step forward in evolving the field of metabolomics. Ph.D.

Targeting the Tumor Microenvironment to Enhance the Efficacy of Tumor-Targeted Antibody Therapy

Thu, 08/21/2014 - 15:26
Targeting the Tumor Microenvironment to Enhance the Efficacy of Tumor-Targeted Antibody Therapy Tumor-targeted antibody therapy has had a major impact on reducing morbidity and mortality in a wide range of cancers. Antibodies mediate their anti-tumor activity in part by activating immune effector cells; however, the tumor microenvironment is enriched with cellular and soluble mediators that actively suppress generation of anti-tumor immunity. Here, we investigate the potential of prospectively identifying and neutralizing an immunomodulatory soluble mediator within the tumor microenvironment to enhance therapeutic efficacy of the HER2-directed antibody trastuzumab. Using the D5-HER2 cell line and an immunocompetent human HER2 transgenic animal (hmHER2Tg) in which human HER2 is seen as a self-antigen, we determined that IL-4 was present in the tumor microenvironment and produced by both tumor and stromal cells. Furthermore, IL-4 neutralization using the anti-IL-4 antibody 11B11 enhanced the efficacy of trastuzumab and modulated the tumor microenvironment. For example, IL-4 neutralization resulted in reduced levels of myeloid chemoattractants CCL2, CCL11, and CXCL5 in the tumor microenvironment. Combination therapy with 11B11 and trastuzumab resulted in a reduction of tumor-infiltrating CD11b+CD206+ myeloid cells compared to monotherapy.; Additionally, we sought to identify the molecular mechanisms by which D5-HER2 cells regulate IL-4 in vitro. Using a siRNA-based screening approach, we identified STAT5A as a novel negative regulator of IL-4 expression in D5-HER2 cells. Collectively, these data suggest that IL-4 neutralization enhances the efficacy of trastuzumab by influencing the phenotype of myeloid cells within the tumor microenvironment and provides further rationale for combining tumor-targeted antibody therapy with agents that neutralize factors in the tumor microenvironment that suppress generation of productive anti-tumor immune responses. Ph.D.

Knowing The Known Unknown: Comparing The Religious Epistemologies of Edward Schillebeeckx and Gendun Chopel In Response To Modernity

Thu, 08/21/2014 - 13:00
Knowing The Known Unknown: Comparing The Religious Epistemologies of Edward Schillebeeckx and Gendun Chopel In Response To Modernity What can one ever know for certain? On what basis or "authority" can one ever assert any knowledge of objective "truth"? Such questions are not only quite common within much of contemporary society but are indeed becoming more and more common within religious communities and among the individual practitioners that comprise them. This study investigates how a comparison between the Catholic theologian Edward Schillebeeckx's controversial reading of Thomist philosophy and the Tibetan Buddhist Gendun Chopel's challenge to the standard Geluk teaching of Tsongkhapa's Madhyamaka philosophy might assist in rethinking conceptions of religious knowledge, particularly regarding questions of the authority of religious experiences, founders, and communities, within contemporary society. By employing an adapted and expanded version of Aaron Stalnaker's "Bridge Concepts" methodology from his work of comparative religious ethics, Overcoming Our Evil, this study seeks to show how Gendun Chopel's Buddhist Madhyamaka approach to the questions of knowledge in light of cultural conventionality and historical contingency can possibly better inform a Christian theological response to similar questions of modern society. Utilizing a wide variety of methodical approaches to establish an imaginary dialogue between these two thinkers, this comparison seeks to remain embodied in the thought and praxis of actual individuals, rather than simply in abstract religious ideas, and yet still firmly embedded within the conversations and trajectories of their broader religious traditions. Moreover, in order to ensure a focus on cultural relevancy and theological expediency, the comparison maintains a consciously constructive orientation--both in the creation of the dialogue itself as well as in its conclusions. Thus the final chapter constructively combines and contrasts the insights of both thinkers regarding the knowability of ultimate truth in order to develop new possible approaches to epistemology that will seek to assist the contemporary believer in avoiding the problematic nihilism of a purely subjectivist epistemology--which is so rampant in the contemporary "postmodern" milieu-- while still always maintaining and sharpening the practitioner's humility towards discourses on metaphysics through the critical eye of a deconstructive apophaticism. Ph.D.

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