Date: Sun, 8 Apr 2001 14:14:30 -0400 (EDT)
The main aim of the journal is to publish scientific work on the role of
molecular asymmetry in both biologically active and
non-biologically active molecules in respect to their pharmacological,
biological, and chemical properties. Drugs, pesticides, and
other xenobiotics will be a major interest.
Papers on the chemistry (physiochemical, preparative synthetic, and
analytical), pharmacology, clinical pharmacology,
toxicology, and other biological aspects of chiral molecules will be
Among the topics to be covered are stereospecific synthesis, stereoselective
analysis, preparative separation of chiral molecules, the influence of
chirality on pharmacokinetics (absorption, distribution, protein binding,
biotransformation, etc.), the influence of chirality on pharmacodynamics
(drug-receptor interactions, pharmacological and toxicological activity),
and the influence of chirality on clinical pharmacology (therapeutic index
and response, bioavailability, adverse drug reactions, drug-drug
interactions). Papers will also be published on regulatory and legal aspects
in the development, testing, and marketing of chiral compounds.
Available by subscription only.
Editor: John Caldwell