Publisher: BioMed Central
Genome Integrity is an open access journal that publishes research on all aspects of genome integrity, the cellular processes underlying maintenance of genome stability, and the effects of instability.
The processes that regulate genome integrity maintenance include sensing, signalling and repair of DNA damage, processing of DNA damage in the context of chromatin and chromosomes, cell cycle checkpoint control and control of apoptosis. Effective maintenance of genome integrity is essential for normal cell division, tissue homeostasis, healthy organismal ageing and prevention of diseases such as cancer. A number of model systems including single cell organisms and various higher plant and animal species, as well as studies of human cells/tissues or patients are required to understand how genome integrity maintenance affects ageing and development of cancer.
The journal is focused on understanding the processes that regulate the maintenance of genome integrity. Topics include, but are not limited to:
* induction of DNA damage
* sensing, signalling and repair of DNA damage
* processing of DNA damage in the context of chromatin and interphase chromosomes
* metaphase chromosome alterations
* telomere maintenance
* cell cycle regulation
* control of apoptosis
* effects of genotoxic stress including radiation and chemicals
* genome integrity and ageing
* genome integrity and cancer
Manuscript submission via online system.
M Prakash Hande
Abstracts available online. Articles available in HTML and PDF format.
Current Issue: Volume 1 2010
Date: 6 January 2011