Journal of Translational Medicine
Publisher: BioMed Central
Journal of Translational Medicine is an Open Access, peer-reviewed online
journal focussing on information derived from human experimentation so as to
optimise the communication between basic and clinical science.
Journal of Translational Medicine aims to improve the communication between
basic and clinical science so that more therapeutic insights may be derived
from new scientific ideas - and vice versa. Translation research goes from
bench to bedside, where theories emerging from preclinical experimentation
are tested on disease-affected human subjects, and from bedside to bench,
where information obtained from preliminary human experimentation can be
used to refine our understanding of the biological principles underpinning
the heterogeneity of human disease and polymorphism(s). The former direction
has received much attention, usually through exploratory clinical studies
referred to as "phase 1" trials. The latter, however, has been largely
The outcomes of clinical trials are usually poor and experimenters are
encouraged not to publish, believing that journals are less likely to
publish "negative" results. Consequently most of this "transitional
information" remains hidden from the wider research community.
Results of a clinical study originating from a sound scientific rationale
should be considered equally important, whether negative or positive, for
two broad reasons:
* knowledge of negative results will discourage researchers from publishing
a similar study
* important biological information could offer important insights into the
reasons for failure and suggest remedies.
Against this backdrop, translation research has gained popularity, fuelled
by the lack of significant progress in the treatment of cardiovascular,
infectious, autoimmune and degenerative pathology, as well as cancer.
Journal of Translational Medicine therefore aims to provide a home for this
Journal of Translational Medicine considers the following types of articles:
* Research - should exemplify the conduct of outstanding clinical research
by including the collection of samples and analysis tools aimed at
understanding the biology of the disease and its treatment.
* Study protocols - should describe proposed or ongoing research, with a
detailed account of the hypothesis, rationale and methodology of the study.
The study design must be adequate to answer the clinical question.
* Methodology - should present a new experimental method, test or procedure.
The method may either be completely new or a better version of an existing
* Reviews - comprehensive, authoritative, descriptions of any subject within
the journal's scope; these articles are usually written by opinion leaders
that have been invited by the Editorial Board.
* Commentaries - short, focused and opinionated articles on any subject
within the journal's scope. These articles are usually related to a
contemporary issue, such as recent research findings, and are often written
by opinion leaders invited by the Editorial Board.
Manuscripts should be submitted electronically to Journal of Translational
Medicine using the online submission system.
Dr Francesco Marincola, MD
National Institutes of Health
Abstracts available online. Articles available in HTML and PDF format.
Current Issue: Volume 3:39 (28 October 2005)
Date: 31 October 2005